NF-κB Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-κB-Inducing Kinase and IκB Kinase

NF-kB Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-kB-Inducing Kinase and IkB Kinase

NF-κB Activation: The IκB Kinase Revealed?

(Baeuerle and Baltimore, 1996). More than a decade ago, the transcriptional activator In vivo, phosphorylation of IkB occurs when it is comNF-kB was described as a protein that bound to a speplexed with NF-kB and does not cause dissociation of cific DNA site in the intronic enhancer of the immunothe complex. Rather, it signals ubiquitination of IkB, globulin k light chain gene (Sen and Baltimor...

Protein kinase C-associated kinase regulates NF-κB activation through inducing IKK activation.

Activation of the transcription factor NF-κB induced by extracellular stimuli requires IKKα and IKKβ kinase activity. How IKKα and IKKβ are activated by various upstream signaling molecules is not fully understood. We previously showed that protein kinase C-associated kinase (PKK, also known as DIK/RIP4), which belongs to the receptor-interacting protein (RIP) kinase family, mediates the B cell...

The IκB kinase complex in NF-κB regulation and beyond.

The IκB kinase (IKK) complex is the signal integration hub for NF-κB activation. Composed of two serine-threonine kinases (IKKα and IKKβ) and the regulatory subunit NEMO (also known as IKKγ), the IKK complex integrates signals from all NF-κB activating stimuli to catalyze the phosphorylation of various IκB and NF-κB proteins, as well as of other substrates. Since the discovery of the IKK comple...

Zebrafish IκB Kinase 1 Negatively Regulates NF-κB Activity

The I B kinase (IKK) activity is critical for processing I B inhibitory proteins and activating the NFB signaling, which is involved in a series of physiological and developmental steps in vertebrates [1–4]. The IKK activity resides in two catalytic subunits, IKK1 and IKK2, and two regulatory subunits, NEMO and ELKS [5–8]. IKK2 is the major cytokine-responsive I B kinase [9–11] because depletio...